[Ebooks] Sphingolipids and Metabolic Disease (Advances in Experimental Medicine and Biology) 2

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Sphingolipids and Metabolic Disease (Advances in Experimental Medicine and Biology) 2 

Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in

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