[Ebooks] Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 3

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Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 3

Description:

Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity.

This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

Provides updated and revised chapters for in-depth discussions of toxicologic pathology for the protection of the environment and food supplies

Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology

Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Preface

Since its inception three decades ago, Haschek and Rousseaux’s Handbook of Toxicologic Pathology has been a comprehensive resource covering fundamental knowledge and skills as well as key technical procedures essential for the proficient practice of toxicologic pathology. The reference has found a home in the libraries of numerous academic, government, and industrial institutions engaged in basic and applied biomedical research around the globe, and in doing so has become an indispensable reference for many toxicologic pathologists, toxicologists, regulators, physicians, biomedical researchers, and students. Indeed, the Handbook has been recognized by many as the most authoritative single source of information in the field due to the breadth and depth of coverage for this field .

Prior to publication of the inaugural Handbook edition in 1991, information regarding toxicologic pathology had to be gleaned in a piecemeal manner by reading articles in various toxicology and the few toxicologic pathology journals. The success of the one-volume 1st edition and the expanded roles of toxicologic pathologists over time led in due course to the release of updated Handbook versions in subsequent years: a two-volume 2nd edition in 2002 and a three-volume 3rd edition in 2013. The many scientific advances, ongoing and extensive collaboration among global societies of toxicologic pathology, and new regulatory guidance that has occurred since release of the 3rd edition amply prove that another rendition is necessary to maintain, and indeed enhance, the value of this resource to practitioners of the toxicologic pathology craft. For this reason, the Editors and Associate Editors are pleased to offer this new and expanded Handbook to aid your explorations of the toxicologic pathology field.

This 4th edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology has been extensively updated to continue its comprehensive coverage. This update required extensive expansion, which was initially conceived as a four-volume text. However, the unrelenting explosion of information in this field instead has necessitated that this new edition instead be rendered as a five-volume set where the contents of Volume 2 of the 3rd edition now are divided between Volumes 2 (“Toxicologic Pathology in Safety Assessment”) and 3 (“Environmental Toxicologic Pathology and Selected Toxicant Classes”). Volume 3 will be the first volume or book completely dedicated to environmental pathology since the 1990s.

For the 4th edition, the new five-volume design distributes important concepts in the following way.

• Volume 1 (released in 2022) covers “Principles and the Practice of Toxicologic Pathology,” including such key topics as basic concepts in biology, pathology, pharmacology, and toxicology as they intersect in the field of toxicologic pathology (Chapters 2e8); primary methods in toxicologic pathology (Chapters 9e16); overviews of major models employed in toxicologic research (Chapters 17e24); and essential practices in generating and interpreting toxicologic pathology data (Chapters 25e29). New chapters in Volume 1 address absorption, distribution, metabolism, and excretion (ADME) principles for biomolecules; toxicologic pathology considerations in developmental and reproductive toxicity (DART) testing; digital pathology; and various animal models including rodents, rabbits, dogs, nonhuman primates, and alternative models (e.g., in silico, ex vivo). Because of the recent decision to divide Volume 2, leading to a five-volume 4th edition, chapter cross-referencing in the initially released Volume 1 (by volume and chapter number) may be incorrect when referring to contents of other volumes.

• Volume 2 (released in 2023) addresses “Safety Assessment and Toxicologic Pathology.” Safety assessment covers the application of toxicologic pathology in developing specific product classes (Chapters 1e12) and principles of data interpretation Chapters 13e17). New chapters in this section consider fundamental attributes of novel therapeutic classes (nucleic acid- and protein-based pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, medical devices, vaccines); agricultural and bulk chemicals and differentiation of adverse from nonadverse effects. These chapters address both pathology and regulatory issues. Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field.

Volume 3 is dedicated to “Environmental Toxicologic Pathology and Selected Toxicant Classes.” This volume covers toxicologic pathology as it relates to food (Chapter 2), nutrition (Chapter 3), and selected toxicant classes in the environment that affect human and animal health (Chapters 4e14). New chapters include herbal products (Chapter 4) and animal- and bacteria-derived toxins (Chapters 8 and 9); for these chapters, particular attention has been paid to the role of such substances in formulating new therapies (either as the active agent or as important contaminants of the manufacturing process). All previous chapters (e.g., endocrine disruptors, heavy metals, nanoparticulates, poisonous plants, radiation) have been extensively revised and updated. Organspecific environmental diseases will be addressed ivolumes 4 and 5.

• Volumes 4 and 5 provide deep and broad treatment of “Target Organ Toxicity” for major systems, emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. New topics addressed in Volume 4 include the toxicologic pathology of adipose tissue, tendons, and teeth. New information regarding product development and regulatory issues has been incorporated in the organ system chapters for both volumes.

The expanded coverage of nonclinical testing principles and practices, the new material on various models of toxicity, and the toxicologic pathology of novel toxicant classes (especially new therapeutic modalities) will be a particular strength of this new Handbook edition and should and will continue to justify its long-standing reputation for excellence. The Editors do accept that information relevant to toxicity research, hazard identification, and risk assessment and management is ever growing and they acknowledge that readers may benefit by extending their search for up-to-the-minute information in this area to include other textbooks and journals of toxicology and toxicologic pathology.

We would like to thank the dedicated efforts of the Associate EditorsdStacey Fossey and John Vahle (Volume 1), Katie Heinz-Taheny and Dan Rudmann (Volumes 2 and 3), Molly Boyle and Mark Hoenerhoff (Volume 4), and Jeff Everitt and Karen Regan (Volume 5); our incomparable Illustrations Editor, Beth Mahler; and the many chapter authors for their outstanding contributions in bringing this book to fruition. In addition, we wish to specifically acknowledge the significant involvement of many leading toxicologic pathologists as essential subject matter experts in contributing to this and previous editions; many are now retired, and a growing number are deceased including our friends and mentors Charles C. Capen, Victor J. Ferrans, Gordon C. Hard, Adalbert Koestner, Robert W. Leader, Daniel Morton, John F. Van Vleet, and Hanspeter R. Witschi.

• Title: Haschek and Rousseaux’s Handbook of Toxicologic Pathology, Volume 3: Environmental Toxicologic Pathology and Major Toxicant Classes
  
• Author(s): Wanda M. Haschek-Hock, Colin G. Rousseaux, Matthew A. Wallig, Brad Bolon
  
• Publisher: Academic Press
  
• Year: 2023
  
• Edition: 4th Edition
  
• Language: English
  
• Pages: 964
  
• Ebook:  PDF
  
• File size: 137 MB
  
• ISBN Number: 0443161534, 9780443161537
  
• CBID: CBM418
  

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