[Ebooks] Alternative Splicing [RNA] and Disease

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Alternative Splicing [RNA] and Disease

Splicing of the primary RNA transcript, i.e., removal of introns and joining of exons to produce mature mRNAs competent for translation into

proteins, is a quasi-systematic step of gene expression in higher eucaryotes. The full biological significance of splicing has not been appreciated until it was discovered that alternative splicing, that process which allows a primary transcript to yield several distinct mRNAs and consequently several different proteins, is a widespread mechanism. Although we had already recently published in this same series (2003, Volume 31 Ph. Jeanteur, ed.) a book dedicated to the regulation of alternative splicing, we thought it timely to ollow up in this direction by focusing on pathological and therapeutic aspects.

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