Applications of Microdialysis in Pharmaceutical Science

Microdialysis is a very useful sampling tool that can be used in vivo to acquire concentration variations of protein - unbound molecules located in interstitial or extracellular spaces. This technique relies on the passive diffusion of substances across a dialysis membrane driven by a concentration gradient. After a microdialysis probe has been implanted in the target site for sampling, generally a blood vessel or tissue, a perfused solution consisting of physiological buffer solution flows slowly across the dialysis membrane, carrying away small

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