Anti-VEGF {Devels. in Opthalmology]

The development of vascular endothelial growth factor inhibitors for the treatment of ocular neovascularization and macular edema can be regarded as the beginning of a new era in ophthalmological therapy. Before the year 2000, the treatment of any vascular abnormality in the macular region was merely restricted to conventional laser photocoagulation. Indubitably, laser treatment represents a destructive procedure

which leads to a permanent scar and brings about a retinal sensitivity deterioration in all cases. Since 2000, photodynamic therapy with verteporfin has been introduced as the first attempt to couple laser energy with a light-sensitive drug in an attempt to