.Antisense Therapeutics 2nd ed

We are now more than 15 years into a large-scale experiment to determine the viability of antisense technology. The challenges of creating a new pharmacological drug discovery platform are prodigious, requiring sizeable investments, long-term commitment, insight, and perseverance. For antisense technology to progress, advances in understanding the behavior of the receptor, RNA, and the behavior of the drugs, oligonucleotide analogs, were necessary. A new medicinal industry, the medicinal industry of oligonucleotides, had to be invented, and numerous drug development challenges—such as creating efficient manufacturing and analytical processes and formulations—had to be overcome.