An Update on Glomerulopathies - Etiology and Pathogenesis

The past several decades have seen dramatic advances in understanding the etiopathogenesis of glomerulonephritis. The science of renal disease has progressed steadily from a discipline focused largely on whole organ physiology, through successive eras of cell and molecular biology, several omics (proteomics, genomics) and now into molecular mapping and personalized medicine. During that time, the processes which initiate and mediate glomerular inflammation have emerged with ncreasing clarity and complexity from early perceptions that they reflected largely immune complex driven processes involving exogenous antigens, antibodies and complement to today's recognition that most are autoimmune in nature.